Automatic Design of Digital Synthetic Gene Circuits from PLoS Computational Biology. They seem to be saying look, real biology isn’t generally digital, and all that continuum behavior means we need a bunch of new and complex tools to do anything with it. However, there are plenty of instances of pseudo-digital biological control systems, and we’ve already got a gigantic toolbox from EE/VLSI world for building very complex digital circuits, so why not limit ourselves to using an artificially digitized subset of biology so we can leverage the existing design tools, and see how far we get? Weird to think of this particular kind of very intimate digitization of life. Talk about historical effects. What would our post-dark-age descendants think, rediscovering a strange class of metabolic networks, in which everything is binary?