Tag: medicine

Shared Links for Apr 30th

  • Transparency means nothing without justice – Government transparency is necessary, but not sufficient. If police violence is recorded and publicized, and nobody cares, it doesn't matter. This is in come sense emblematic of the coup in western propaganda. You don't need to control the media as the Soviets did or the Chinese do, if your population is comfortable enough not to care what's happening out there to someone else, and if their voting patterns are firmly tied to other issues (especially social issues like abortion), the idea of a democratic revolt becomes fairly abstract. I think this where a lot of the government's fear of economic recessions comes from. When people are out of work, or even hungry, suddenly they become a lot more excitable. (tagged: transparency law police politics technology internet )
  • Condensing steam without water – Concentrating solar thermal power stations are ultimately designed to run a steam turbine, just like a gas-fired power plant. That means they need water (to turn into steam). Problematically, most such plants use water as a condensing coolant (70% of Caltech's water usage is as coolant for our 14MW worth of gas-fired power)… which is going to be hard to come by in the desert, where CSP will be built. Thankfully, there's a way to recondense steam without using a water coolant – but it does require a huge cooling tower. Not so great in Pasadena, but probably fine in the Mojave, next to acres and acres of mirrors. (tagged: solar energy technology sustainability green electricity water )
  • Rousing a Latent Defense Mechanism to Fight HIV – It turns out there is a gene in humans that produces a protein which inhibits infection by HIV, but it has a mutation – a premature stop codon – which prevents it from being effectively synthesized. This mutation doesn't exist in most Old World monkeys (and that's apparently why they can't get HIV). Undoing the mutation allows the protein to be synthesized, and grants HIV immunity to human cells. I imagine that undoing bad mutations like this, and our inability to synthesize vitamin C, might be the first place we see human germ-line engineering outside of disease avoidance (preventing e.g. cystic fibrosis). Really, these mutations are hard to distinguish from genetic diseases – they're just diseases that we, as a species, have learned to live with. (tagged: genetic engineering hiv aids biology science research plos medicine )
  • Anna in the Middle East – Anna Baltzer is a Jewish American who got a Fulbright fellowship to live in the West Bank in 2005, and document the experiences of Palestinians. She's been giving presentations about it ever since. Some parts of her presentation are available via YouTube too. From the 15 minutes I watched she seemed like a level headed critic. She's speaking in Boulder and Denver in May. (tagged: israel palestine politics fulbright peace war )
  • Twitter + Stimulus = Humans are Gullible – A wonderful demonstration of the power of the confirmatory bias. Twitter is the perfect platform for the injection of random falsehoods. Too short for citations. Instantaneous distribution. Make sure your followers are predisposed to agree with what you say, and you can get them to believe just about anything – within that constraint. Too bad the author seems to think this only applies to conservatives. (tagged: politics twitter statistics propaganda )

Francis Collins at Caltech and the future of genomic medicine

Went to Francis Collins’ afternoon talk “fireside chat” with David Baltimore on the future of medicine, as illuminated by genomic work.  Too much introduction and rambling biographical information, but some good discussion anyway.  I thought his best comments had to do with the positive effects of the open data model that the Human Genome project initiated – it’s had a long lasting impact on the entire field of genomics, and thank goodness!  Also, he mentioned that as of now, there aren’t any major studies seeking to correlate and analyze the relationships between genotypes, phenotypes, and environment in the human population, and that such a study is really what’s needed to truly understand what’s actually heritable, what our real low frequency (rare allele) genetic variation is like, and what kinds of effects environmental factors play.  He pointed out, interestingly, that we don’t need to wait until thousand dollar genomes are available to start this study – what we need to do is get people signed up, and start tracking their health history and environmental factors, and we can sequence them when it becomes cheap enough.  He suggested that we ought to do this for roughly 500,000 people, and that it would likely cost on the order of half a billion dollars a year, and need to run for a few decades.  And then we’d know, and medicine would be forever changed.  He also suggested that those $1000 genomes are likely on the order of 5 years away.  Really, once we’ve got fast, cheap sequencing – this study will almost do itself, so long as we can at some point get access to the medical histories and genomes of people.  The real value add is in starting it now, so we have the information as soon as possible, and in getting all the environmental/lifestyle data, in addition to the healthcare records.

Continue reading Francis Collins at Caltech and the future of genomic medicine