Leveraging digital design in synthetic biology

Automatic Design of Digital Synthetic Gene Circuits from PLoS Computational Biology.  They seem to be saying look, real biology isn’t generally digital, and all that continuum behavior means we need a bunch of new and complex tools to do anything with it.  However, there are plenty of instances of pseudo-digital biological control systems, and we’ve already got a gigantic toolbox from EE/VLSI world for building very complex digital circuits, so why not limit ourselves to using an artificially digitized subset of biology so we can leverage the existing design tools, and see how far we get?  Weird to think of this particular kind of very intimate digitization of life.  Talk about historical effects.  What would our post-dark-age descendants think, rediscovering a strange class of metabolic networks, in which everything is binary?

Population Growth vs. Migration in Boulder and the World

The Boulder Blue Line has a short post entitled This Law Cannot Be Repealed by Albert Bartlett, who is an emeritus professor of Physics at CU, and who is most well known for speaking about the absurdity of “sustainable” growth and what exponential growth really means.  He’s also one of the original architects of Boulder’s “Blue Line”, which has limited growth beyond certain boundaries within the city and county.

I agree with Bartlett on a lot.  Unconstrained population growth is undoubtedly, in a global context, an epic disaster.  In his collection of essays Brave New World Revisited, Aldous Huxley noted of overpopulation that “Unsolved, that problem will render insoluble all our other problems.”  Similarly, the unconstrained geographic growth of towns and cities is a catastrophe, resulting in very low-density, car-dependent development which exacerbates the consequences of population growth by increasing the amount of resources that each individual consumes, in terms of land and energy and material goods.

Parks are for People

Urban density and good public space make scenes like this possible.

Continue reading Population Growth vs. Migration in Boulder and the World

Population Growth vs. Migration in Boulder and the World

The Boulder Blue Line has a short post entitled This Law Cannot Be Repealed by Albert Bartlett, who is an emeritus professor of Physics at CU, and who is most well known for speaking about the absurdity of “sustainable” growth and what exponential growth really means.  He’s also one of the original architects of Boulder’s “Blue Line”, which has limited growth beyond certain boundaries within the city and county.

I agree with Bartlett on a lot.  Unconstrained population growth is undoubtedly, in a global context, an epic disaster.  In his collection of essays Brave New World Revisited, Aldous Huxley noted of overpopulation that “Unsolved, that problem will render insoluble all our other problems.”  Similarly, the unconstrained geographic growth of towns and cities is a catastrophe, resulting in very low-density, car-dependent development which exacerbates the consequences of population growth by increasing the amount of resources that each individual consumes, in terms of land and energy and material goods.

Parks are for People

Urban density and good public space make scenes like this possible.

Continue reading Population Growth vs. Migration in Boulder and the World

Pedestrianization Done Right

A post from David Hembrow in the Netherlands on what it takes to make pedestrianized spaces work by examining a new living/shopping development in Assen.  Make it clear that pedestrians have right of way over everyone, but make it easily accessible to bikes.  However, ensure that it isn’t a throughfare for bikes — only cyclists actually coming to the place as a destination should be there.  If you exclude both bikes and cars from the space, then you decrease the relative attractiveness of cycling unnecessarily, encouraging people to drive.

The Missing Wikipedians

An interesting analysis of the cultural biases of the Wikipedia.  As participation by the developing world increases, we need to come up with a better way of assessing “notability”.  Especially with English, shared language is not shared culture or context.  We in the west may see Kenyan pop cultural references as unworthy of note… but that’s not how they see it!  Personally I’d rather see it become a truly global repository of knowledge.  The less insular we are, the better.

Education will not be fixed, it will evolve

It seems like there have been calls to “fix” our education system in the US for decades.  The Apollo program’s Saturn V engines were largely built by young engineers and scientists.  Their educations were influenced by the Sputnik-inspired National Defense Education Act of 1958, which despite its codified McCarthyism was probably a good thing.  Those kids of my parents’ generation were probably also directly inspired by Sputnik, and the Amazing Stories of Arthur C. Clarke and Isaac Asimov.  Even my Seventh Day Adventist dad wanted to study physics in college, until he encountered the associated math.

Sputnik 1

If it takes a Sputnik moment to “fix” education, we may be out of luck this time around.

This burst of attention to (and funding for) science and mathematics education was, like the entire Apollo program, the product of a nationalist fear that we were “falling behind” the Soviets.  Despite Thomas Friedman’s ongoing attempts to frame China’s production and adoption of clean energy technologies and as a modern Sputnik Moment, I doubt it’s in the cards.  Not without some pretty dramatic focusing moment, and not without exiling the fossil fuel industries from US politics.  It’s also just not the same kind of story as your newly atomic ideological arch nemesis lobbing rocks over your territorial boundaries, well out of reach.  We will not be terrified by China’s solar panels, nor even, it seems, by their monopoly on the production of rare earths.

Continue reading Education will not be fixed, it will evolve

Anki: intelligent digital flashcards

Aaron recently pointed me at Anki, an open-source flashcard system.  I’m using it to refresh my Spanish language skills, but it’s a very generalized system that one can use to remember just about anything.  You create linked “facts” (n-sided flash cards) and study them on your desktop, the web, or even a phone.  It reduces the overhead in studying a lot, and there are thousands of “shared” decks of flashcards you can use or build on.

The Rise of the New Global Elite

A nice long-form piece from The Atlantic on the phenomenon and dangers of the New Plutocrats… not just Lloyd Blankfein and his parasitic bankster ilk, but nearly everyone who stands at the so-called Commanding Heights of industry, including productive innovators.  The developed world was all to hot to globalize the economy when we thought we’d always stay on top.  But that was ridiculous of course.  Now “on top” is just a few people scattered all over, and most of us will slide toward the very large bottom if we’re not careful.

Code 46 and the dearth of thoughtful science fiction

I recently watched Code 46 again.  When I first saw it a few years ago I didn’t like it very much, but this time it seemed more interesting.  The storyline doesn’t hold together very well, and from a scientific point of view there are some painful gaffes, but it’s at least attempting to explore some important present and near-future issues, which is more than I can say for most science fiction films.  That makes me sad, since I feel at its best, science fiction helps us understand how we interact with and relate to technology, and how technology changes the way we interact and relate to each other.  The fact that there’s so little mainstream science fiction trying to do this today is frightening.  We’re just blindly stumbling forward into the darkness.  Maybe the best thoughtful sci-fi I can recall from the recent past is Gattaca, which depicts in a very stylized way a future society which is starkly divided between those who are genetically enhanced and those who are not.  Gattaca is pretty clearly unconcerned with the details as opposed to the implications of its premise, and that makes it easier to gloss over whatever issues it has.  It’s less clear that Code 46 is this self aware, but at least on a second viewing, I was willing to give it the benefit of the doubt.  Be warned, there are spoilers below.

Continue reading Code 46 and the dearth of thoughtful science fiction