Francis Collins at Caltech and the future of genomic medicine

Went to Francis Collins’ afternoon talk “fireside chat” with David Baltimore on the future of medicine, as illuminated by genomic work.  Too much introduction and rambling biographical information, but some good discussion anyway.  I thought his best comments had to do with the positive effects of the open data model that the Human Genome project initiated – it’s had a long lasting impact on the entire field of genomics, and thank goodness!  Also, he mentioned that as of now, there aren’t any major studies seeking to correlate and analyze the relationships between genotypes, phenotypes, and environment in the human population, and that such a study is really what’s needed to truly understand what’s actually heritable, what our real low frequency (rare allele) genetic variation is like, and what kinds of effects environmental factors play.  He pointed out, interestingly, that we don’t need to wait until thousand dollar genomes are available to start this study – what we need to do is get people signed up, and start tracking their health history and environmental factors, and we can sequence them when it becomes cheap enough.  He suggested that we ought to do this for roughly 500,000 people, and that it would likely cost on the order of half a billion dollars a year, and need to run for a few decades.  And then we’d know, and medicine would be forever changed.  He also suggested that those $1000 genomes are likely on the order of 5 years away.  Really, once we’ve got fast, cheap sequencing – this study will almost do itself, so long as we can at some point get access to the medical histories and genomes of people.  The real value add is in starting it now, so we have the information as soon as possible, and in getting all the environmental/lifestyle data, in addition to the healthcare records.

Continue reading Francis Collins at Caltech and the future of genomic medicine

Denver RTD: ditch Amtrak people at Union Station

Dear Denver RTD,

I had the pleasure yesterday of riding my bike 19 miles from Lakewood to downtown Denver almost exclusively on cycling paths, all the way to Union Station, where I intended to catch a BX up to Boulder. I understand you are in the process of re-developing the old rail station to be a major multi-modal transit hub for the city, with a great deal of high density mixed use transit oriented development in the vicinity.  So far, it looks absolutely great, and I applaud you for working with the city and developers to continue central Denver’s urbanization in an intelligent way, and make long term investments in non-automotive transportation infrastructure for the region.  I am considering re-locating to the Denver area from Southern California when I finish my PhD, to work at the National Renewable Energy Lab in Golden, and the region’s excellent transit system is one of the reasons.  I prefer not to own a car or drive, for economic, fitness, and environmental reasons, and having high density mixed use developments and effective multi-modal transit options makes living without a car much more pleasant and convenient.

Continue reading Denver RTD: ditch Amtrak people at Union Station

The Edge’s Annual Question for 2009

From the Edge, and their annual “World Question Center” for 2009.

What will change everything?  What game changing scientific ideas and developments do you expect to live to see?

Many thoughtful answers, including a particularly good one about climate, likening potential abrupt state changes to unpredictably soundly sleeping giants that we do not want to awaken:

Unfortunately, we are discovering more giants that are probably lighter sleepers than the thermohaline circulation (THC). Seven others — all of them potential game-changers — are now under scrutiny: (1) the disappearance of summer sea-ice over the Arctic Ocean, (2) increased melting and glacier flow of the Greenland ice sheet, (3) “unsticking” of the frozen West Antarctic Ice Sheet from its bed, (4) rapid die-back of Amazon forests, (5) disruption of the Indian Monsoon, (6) release of methane, an even more potent greenhouse gas than carbon dioxide, from thawing frozen soils, and (7) a shift to a permanent El Niño-like state. Like the THC, should any of these occur there would be profound ramifications — like our food production, the extinction and expansion of species, and the inundation of coastal cities.

We’re wallowing in the fat tails.

Wall Street’s Game of Risk

A relatively thoughtful piece from The New York Times Magazine on the risk metrics used by Wall Street, especially the now notorious Value at Risk (VaR).  However, it still seems like neither the author nor the risk managers they interviewed really get what Taleb is saying.  Or possibly they’re just not willing to admit the implications of what he’s saying: that market outcomes, especially when investing is focused on the short term, are dominated by so-called “rare” events.  And that the consequence (as one of the managers even says outright), is that a lot of the investment banks don’t really have a business model.

Except, of course, for the fact that they can count on the public coffers if they all arrange to go bankrupt simultaneously.  Better, in this case, to fail in a conventional way along with everyone else, and be bailed out, than to play your own game for the long term, like Warren Buffet, and either succeed unconventionally, or have to take responsibility for your own failures, which are then likely not to take place at the same time industry wide.

We’re playing the same game of fat-tails chicken with Earth’s climate, and that story will eventually have the same ending if we are unable to generalize the lessons of this relatively innocuous financial disaster.

Time Lapse Eyes

To plan long term we need time lapse eyes. We need to sense the world on geologic and evolutionary timescales. This is outside of our visceral experience. Astronomers and biologists and geologists get some sense of deep time, but it’s still not an experience. We need to build these eyes for ourselves.

Energy efficiency portfolio standards needed

Implementing a national energy efficiency portfolio standard (EEPS) are just as important as, if not more important than renewable portfolio standards (RPS), and will go a long way toward making aggressive RPSs attainable, but aren’t getting much in the way of mindshare.  More info from the DoE, and the American Council for an Energy Efficient Economy (ACEEE).  EEPS are also a much cheaper (i.e. more profitable) way to cut carbon than current renewables.

Barnett’s Department of Everything Else

I first came across Thomas PM Barnett via his TED talk last year.  He’s an engaging speaker (PowerPoint performance artist might be more accurate), and he has interesting ideas about how globalization works, and what the US military’s role has been, is, and should be.  I’ve followed his blog on and off ever since.  I’m fascinated with him because a huge amount of what he says rings true, and unusually frank, but a little bit of it seems jarring. Last night I watched his full-length brief and took notes, to try and figure out what exactly it was that I disagree with.

Continue reading Barnett’s Department of Everything Else

Machine Readable Financial Reporting

The SEC will soon require machine readable reporting of all financial data, using an XML based markup language known as XRBL (the eXtensible Business Reporting Language).  Holy crap.  Yes, this could have been done a decade ago in theory, but apparently it takes some serious mess to get anyone thinking at the SEC.  Probably bad for Morningstar‘s financial-data-silo business model, but good for just about everyone else.  Will spur a lot of financial transparency, as machines can be easily utilized to find patterns and irregularities in corporate and mutual fund reports, in near real time.  I don’t think most people give this kind of development the credit it deserves.  Long term, machine readability of all law and legal requirements will change the face of regulation, democracy, and ultimately, law itself.

What is the Fed doing?

Trying to keep track of all the shenanigans innovation going on at the Federal Reserve is difficult.  Econbrowser and Interfluidity among others have been trying to help…  but every time I read about how our money system works, I find my head spinning in incredulity.  And that’s just when I’m reading about how it’s “supposed” to work.  It’s been getting more confusing lately.

Continue reading What is the Fed doing?